How does melatonin influence the skin and the aging process?

Melatonin is a key molecule in preventing skin aging due to its unique antioxidant and anti-inflammatory properties, which make it a standout in the cosmetics world. These protective effects help combat free radicals that damage skin cells, one of the main causes of fine lines, wrinkles, and loss of elasticity.

Melatonin also stimulates the production of ATP (adenosine triphosphate) , the primary source of cellular energy. This energy boost is essential for maintaining optimal cell function, resulting in firmer, younger, and healthier-looking skin. Furthermore, melatonin's ability to improve mitochondrial function gives it a unique restorative role, helping to regenerate damaged mitochondria and prevent cell death—two critical factors in the fight against premature aging.

What happens when melatonin levels are low?

As we age, especially after ages 35-40, natural melatonin production declines. This decline affects both pineal melatonin (responsible for regulating sleep-wake cycles) and extrapineal melatonin , which is produced in various tissues, including the skin.

1. Pineal melatonin : Produced in the pineal gland, this melatonin regulates circadian rhythms, which are vital for proper cell regeneration during the night. As we age, the reduction in melatonin disrupts these rhythms, resulting in less repaired skin that is more vulnerable to external damage.

2. Extrapineal melatonin : This version is found in the skin and other tissues, where it acts as an antioxidant and anti-inflammatory defense. With decreased extrapineal melatonin, the skin loses an important layer of protection, becoming more prone to sun damage, pollution, and oxidative stress. This also affects cells' ability to generate energy through mitochondria , decreasing their vitality and regenerative capacity.

The combination of these effects accelerates the aging process and reduces skin quality, manifesting as loss of firmness, the appearance of dark spots, and a dull complexion.

How can we restore melatonin levels and when is the best time?

To determine whether melatonin is necessary to restore normal levels, it is advisable to measure melatonin levels through a saliva test, as melatonin is excreted through saliva. This test will assess the circadian rhythm of melatonin and detect any deficiency. With this information, the best time of day to administer melatonin can be determined, maximizing its effectiveness.

In addition, a blood test is useful for assessing the body's redox and inflammatory status, providing more accurate guidance on cellular damage.

Are cosmetic products with melatonin effective?

Cosmetic products containing melatonin, such as anti-aging creams and melatonin serums , are highly effective when they include an adequate dose of this molecule in their formulation. Melatonin must reach specific concentrations to be effective at the cellular level, and their formula must be designed to prevent its release into the general circulation, optimizing its local action on the skin.

MEL13 is an example of cosmetic innovation that harnesses the properties of melatonin. Developed by Pharmamel, a spin-off of the University of Granada, this product line includes patented moisturizers , serums , and repair creams , formulated to penetrate deep into the different layers of the skin without reaching the circulation. This approach allows melatonin to act at the mitochondrial level, from the cell nucleus to the cytoplasm, providing visible regeneration and improving skin texture, luminosity, and firmness.

The combination of a high concentration of melatonin and targeted release technology distinguishes MEL13 from other products on the market. These cosmetics not only offer a profound anti-aging effect but also support skin recovery in cases of dermatitis and after treatments such as radiation therapy, where the skin requires extra support for its regeneration and defense.

What skin types can benefit from melatonin?

Melatonin in cosmetics is suitable for all skin types , including sensitive skin and skin affected by external factors such as sun exposure, pollution, and intensive dermatological treatments. MEL13 products are specially formulated to provide a restorative effect on mature skin, showing signs of fatigue or dehydration, and skin exposed to procedures that compromise its health and protective barrier.