How does melatonin influence the skin and the aging process?

Melatonin is a key molecule in preventing skin aging due to its unique antioxidant and anti-inflammatory properties, which make it a standout in the cosmetics world. These protective effects help combat free radicals that damage skin cells, one of the main causes of fine lines, wrinkles, and loss of elasticity.

Melatonin also stimulates the production of ATP (adenosine triphosphate) , the primary source of cellular energy. This energy boost is essential for maintaining optimal cell function, resulting in firmer, younger, and healthier-looking skin. Furthermore, melatonin's ability to improve mitochondrial function gives it a unique restorative role, helping to regenerate damaged mitochondria and prevent cell death—two critical factors in the fight against premature aging.

What happens when melatonin levels are low?

As we age, especially after ages 35-40, natural melatonin production declines. This decline affects both pineal melatonin (responsible for regulating sleep-wake cycles) and extrapineal melatonin , which is produced in various tissues, including the skin.

1. Pineal melatonin : Produced in the pineal gland, this melatonin regulates circadian rhythms, which are vital for proper cell regeneration during the night. As we age, the reduction in melatonin disrupts these rhythms, resulting in less repaired skin that is more vulnerable to external damage.

2. Extrapineal melatonin : This version is found in the skin and other tissues, where it acts as an antioxidant and anti-inflammatory defense. With decreased extrapineal melatonin, the skin loses an important layer of protection, becoming more prone to sun damage, pollution, and oxidative stress. This also affects cells' ability to generate energy through mitochondria , decreasing their vitality and regenerative capacity.

The combination of these effects accelerates the aging process and reduces skin quality, manifesting as loss of firmness, the appearance of dark spots, and a dull complexion.

How can we restore melatonin levels and when is the best time?

To determine whether melatonin is necessary to restore normal levels, it is advisable to measure melatonin levels through a saliva test, as melatonin is excreted through saliva. This test will assess the circadian rhythm of melatonin and detect any deficiency. With this information, the best time of day to administer melatonin can be determined, maximizing its effectiveness.

In addition, a blood test is useful for assessing the body's redox and inflammatory status, providing more accurate guidance on cellular damage.

Are cosmetic products with melatonin effective?

Cosmetic products containing melatonin, such as anti-aging creams and melatonin serums , are highly effective when they include an adequate dose of this molecule in their formulation. Melatonin must reach specific concentrations to be effective at the cellular level, and their formula must be designed to prevent its release into the general circulation, optimizing its local action on the skin.

MEL13 is an example of cosmetic innovation that harnesses the properties of melatonin. Developed by Pharmamel, a spin-off of the University of Granada, this product line includes patented moisturizers , serums , and repair creams , formulated to penetrate deep into the different layers of the skin without reaching the circulation. This approach allows melatonin to act at the mitochondrial level, from the cell nucleus to the cytoplasm, providing visible regeneration and improving skin texture, luminosity, and firmness.

The combination of a high concentration of melatonin and targeted release technology distinguishes MEL13 from other products on the market. These cosmetics not only offer a profound anti-aging effect but also support skin recovery in cases of dermatitis and after treatments such as radiation therapy, where the skin requires extra support for its regeneration and defense.

What skin types can benefit from melatonin?

Melatonin in cosmetics is suitable for all skin types , including sensitive skin and skin affected by external factors such as sun exposure, pollution, and intensive dermatological treatments. MEL13 products are specially formulated to provide a restorative effect on mature skin, showing signs of fatigue or dehydration, and skin exposed to procedures that compromise its health and protective barrier.

What is coenzyme Q10?

Coenzyme Q10, also known as ubiquinone, is a component of the mitochondrial electron transport chain and participates in cellular respiration, generating energy in the form of ATP, which is necessary to maintain healthy cells. In other words, its main function is to facilitate energy generation in mitochondria, the "power plants" of our cells. At the same time, it is a powerful antioxidant and protects cell membranes from oxidative damage.

Present in all cells of the human body, this fat-soluble molecule is especially abundant in organs with high energy demands, such as the heart, kidneys, and liver. However, with aging and under certain conditions such as stress, chronic illness, or the use of certain medications, coenzyme Q10 levels decrease significantly. This can affect both our health and our skin, making its use in cosmetic products highly recommended for maintaining good cellular balance.

Health benefits of coenzyme Q10

Coenzyme Q10 is known for its extensive health benefits thanks to its role as a regulator of mitochondrial function, promoting energy production, and its antioxidant power:

• Antioxidant power: Neutralizes free radicals responsible for premature aging and degenerative diseases.
• Energy regulation: Improves energy levels by optimizing mitochondrial function, which reduces feelings of fatigue and weakness.
• Immune strengthening: Supports the body's ability to fight infections and promote better recovery.
• Metabolic support: It helps improve insulin sensitivity, making it especially useful for people with type 2 diabetes.
• Muscle recovery: It is ideal for those looking to reduce muscle fatigue or speed up recovery after intense activities.

Uses and applications of coenzyme Q10

Coenzyme Q10 is widely used in both medicine and cosmetics due to its ability to improve mitochondrial function and, consequently, regenerate and protect cells:

In medicine:

• Supplement to treat cardiovascular diseases, such as heart failure or high blood pressure.
• Support for neurological disorders and degenerative diseases, thanks to its antioxidant capacity.
• Use as a preventative treatment for migraines and chronic headaches.

In cosmetics:

• In anti-aging creams it improves firmness, reduces wrinkles and diminishes expression lines.
• Strengthens the skin barrier and protects the skin from pollution and other external aggressors.
• It stimulates cell regeneration and improves skin radiance, making it an essential ingredient for combating aging. Mel13 includes coenzyme Q10 in its entire product range at a high concentration for maximum effectiveness.

Where can I find coenzyme Q10 naturally?

Although the human body produces this molecule, there are foods rich in coenzyme Q10 that can help you maintain optimal levels:

• Meats and fish: Organ meats such as liver and kidneys, as well as fatty fish such as salmon, mackerel, and tuna.
• Nuts and seeds: Walnuts, almonds, pistachios and sesame seeds.
• Green leafy vegetables: Spinach, chard, and broccoli are ideal for including in your daily diet.
• Legumes: Soybeans, lentils, and peas are excellent options for plant-based diets.

However, food does not provide sufficient amounts to meet the body's needs, making supplements and specialized products an effective alternative for increasing coenzyme Q10 levels.

Coenzyme Q10 and cardiovascular health

Coenzyme Q10 is known for its positive impact on the cardiovascular system, supported by numerous medical studies published in high-impact journals. Among its most notable benefits:

• Improved cardiac performance: Optimizes heart muscle function, especially in people with congestive heart failure.
• Reduction of blood pressure: Helps maintain balanced blood pressure, reducing the risk of hypertension.
• Prevention of oxidative damage: Protects arterial walls, reducing the formation of plaques that can block arteries.
  These benefits make coenzyme Q10 a recommended supplement for those seeking to maintain cardiovascular health, especially as a support for people on drug treatments that reduce its levels.

Coenzyme Q10 and aging

One of the most important applications of coenzyme Q10 is its use in skin care. As we age, mitochondria are damaged, and cells' ability to produce energy decreases. The consequence is increased cell death, resulting in loss of elasticity, the appearance of wrinkles, and a lack of radiance. Coenzyme Q10 helps:

• Reduce the signs of aging: Its powerful antioxidant action protects cells from oxidative stress, slowing down aging.
• Improve firmness and elasticity: It stimulates the production of collagen and elastin, essential for firmer, smoother skin.
• Revitalize tired skin: Increases cellular energy, restoring vitality and natural shine.
  In our MEL13 products, coenzyme Q10 works in combination with other active ingredients such as melatonin, maximizing its benefits and delivering visible results in a short time.

How the combination of coenzyme Q10 and melatonin works in skin care

The combination of coenzyme Q10 and melatonin is a revolution in anti-aging cosmetics. Melatonin increases the function of mitochondrial respiratory chain complexes, and coenzyme Q10 facilitates electron transport. What does this mean? This combination of active ingredients is unique for regenerating our mitochondria, improving cellular function, and helping the skin recover from accumulated damage. This synergy:

• Boosts nighttime cellular repair: Promotes the regeneration of damaged tissues while you sleep.
• Offers advanced antioxidant protection: Both ingredients work together to neutralize free radicals and prevent premature aging.
• Hydrates and strengthens the skin barrier: Leaves skin more resilient and radiant.
  Mel13 and Mel13 Plus are clear examples of how this combination of active ingredients can effectively and lastingly transform the skin.

Opinions from users who use creams with melatonin and coenzyme Q10 such as MEL13 and MEL13 Plus

Users who have incorporated MEL13 and MEL13 Plus into their routine highlight its effectiveness and visible results. They particularly highlight that their skin becomes more luminous and expression lines are noticeably reduced. Furthermore, their skin appears more hydrated, firmer, and protected. These experiences confirm that the combination of melatonin and coenzyme Q10 offers real and visible solutions for radiant, luminous skin.

Conclusions on coenzyme Q10 and its health benefits

Coenzyme Q10 is an essential active ingredient for overall health and skin care. Its antioxidant, energizing, and regenerative benefits make it a comprehensive solution for combating aging and improving vitality. When combined with melatonin, optimal results are achieved. The MEL13 product line exclusively incorporates melatonin and coenzyme Q10 in its formulation, achieving extraordinary results.